Votrient Uses

Votrient is licensed to treat advanced renal cell carcinoma and soft tissue sarcoma. It is approved for adults only, as it has not been adequately studied in children. This medicine works by blocking the action of a certain enzyme that the cancer cells need to grow and multiply. Some off-label uses for Votrient include the treatment of thyroid or pancreatic cancer.

What Is Votrient Used For?

Votrient® (pazopanib) is a prescription medication approved to treat people with the following types of cancer:
  • Advanced renal cell carcinoma
  • Advanced soft tissue sarcoma, after other treatments have been tried.

Using Votrient for the Treatment of Advanced Renal Cell Carcinoma

Advanced renal cell carcinoma (or advanced renal cell cancer) is a type of cancer that begins in the lining of small tubes in the kidneys. Although there are other types of kidney cancer, renal cell cancer is the most common type.
After a cancer diagnosis is made, healthcare providers use a process called staging to describe how far the disease has spread and where it is in relation to the original cancer cells. Staging can be helpful when planning the best treatment approach. In general, there are four stages of kidney cancer. These include the following:
  • Stage I: The tumor is small and has not spread beyond the kidneys.
  • Stage II: The tumor is bigger than in stage I, but still has not spread beyond the kidneys.
  • Stage III: Cancer has spread a little beyond the kidneys, or is found in one lymph node or the main blood vessels of the kidneys.
  • Stage IV: Cancer cells have moved beyond the kidneys, are in at least two lymph nodes, or have spread to other areas of the body. Stage IV kidney cancer is sometimes called advanced kidney cancer.
Treatment for kidney cancer can vary, based on the stage of the disease and a person's age, overall health, and personal preferences. Surgery to remove all or part of the kidney is usually recommended and may cure kidney cancer in the earlier stages. In general, medications are reserved for advanced kidney cancer, when the goal of treatment is to ease symptoms and slow down progression of the disease.
Votrient is one of several medications used in the treatment of kidney cancer. It belongs to a group of drugs called kinase inhibitors. Specifically, Votrient is a tyrosine kinase inhibitor. Sunitinib (Sutent®) is another tyrosine kinase inhibitor approved to treat advanced kidney cancer.
Tyrosine kinase inhibitors also include a group of medications called mammalian target of rapamycin (mTOR) inhibitors. mTOR is a different protein kinase. Temsirolimus (Torisel®) and everolimus (Afinitor®) are examples of mTOR inhibitors approved to treat kidney cancer.
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Votrient Medication Information

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