Votrient Drug Interactions

P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a natural protein that helps remove substances, such as medications, from the tissues in the body so they can be excreted through the urine or feces. Pgp helps remove Votrient from the body. Medications known as Pgp inhibitors decrease the activity of Pgp.
 
When taken with a Pgp inhibitor, Votrient may be removed from the body more slowly, potentially increasing Votrient blood levels and the risk for side effects. Your healthcare provider may choose to monitor you more closely if you take these drugs together, and lower your dose if needed.
 
Pimecrolimus
In general, people taking Votrient should not use pimecrolimus because of an increased risk for infection, lymphoma (cancer of the lymph nodes), and skin cancer. Talk to your healthcare provider before taking these medicines together.
 
Sipuleucel-T
Taking Votrient with sipuleucel-T can make sipuleucel-T less effective. Talk to your healthcare provider before taking these medicines together.
 
Statin Medications
People who take Votrient with simvastatin may have a higher risk for developing increased liver enzymes, which could be a sign of liver damage. It is unknown if this interaction applies to other statin medicines. However, all statin medicines (as well as Votrient) have the potential to cause liver damage. If you take these medicines together and have an increase in your liver enzymes, your healthcare provider may choose to increase your Votrient dosage, or stop your statin medicine.
  
Tacrolimus Ointment
Combining Votrient with tacrolimus ointment may increase your risk for potentially serious side effects, including kidney problems, diabetes, and slow wound healing. You should talk to your healthcare provider before taking these medicines together.
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Votrient Medication Information

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