Votrient Drug Interactions

Combining leflunomide with Votrient may increase your risk for blood cell problems, including abnormally low red blood cells, white blood cells, and platelets. Your healthcare provider will likely monitor you for these problems if you take these medications together.
Live Vaccinations
Live vaccines contain live viruses or bacteria. If you receive a live vaccine while taking Votrient, you might become infected with the virus or bacteria from the vaccine. Also, live vaccines may be less effective in people taking Votrient. Talk to your healthcare provider before receiving a vaccination or immunization while taking this medication.
Other Chemotherapy Medications
Votrient is not approved for use in combination with other chemotherapy medicines. In clinical studies, people who took the medicine with certain other cancer medicines (pemetrexed [Alimta®] and lapatinib [Tykerb®]) had an increased risk for death and life-threatening side effects, including bleeding in the lungs, stomach, or intestines.
QT-Prolonging Medications
Votrient can cause a certain change in the heart rhythm known as QT prolongation. Taking Votrient with other medications that may cause QT prolongation can increase your risk for this potentially life-threatening problem. Your healthcare provider may need to monitor you for this problem if you take Votrient with another QT-prolonging medication.
Combining Votrient with natalizumab may increase your risk for developing infections, including potentially serious infections. It is generally recommended that these medications not be taken together.
P-glycoprotein (Pgp) Inducers
P-glycoprotein is a natural protein that helps remove substances, such as medications, from the tissues in the body so they can be excreted through the urine or feces. Pgp helps remove Votrient from the body. Medications known as Pgp inducers increase the activity of Pgp.
When taken with a Pgp inducer, Votrient may be removed from the body too quickly, potentially making it less effective. Your healthcare provider may choose to monitor you more closely if you take these medications together.
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Votrient Medication Information

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