Simulect Uses

How Does This Medicine Work?

Transplant rejection occurs when the immune system recognizes a transplanted organ as foreign and attacks it. T lymphocytes (a white blood cell type, sometimes simply called T cells) are an important part of the immune response involved in transplant rejection.
An antibody is a protein made by the immune system. Antibodies attach to substances in the body called antigens. Simulect is a manufactured antibody designed to bind to a specific antigen (known as CD25) found on the surface of T cells. Normally, interleukin-2 (a protein made by the body) binds to CD25 and stimulates T cells to mature and divide.
By binding to CD25, Simulect blocks the action of interleukin-2, thus preventing T cells from multiplying. This decreases the number of T cells in the body and reduces the risk for transplant rejection.

Is Simulect Safe for Use in Children?

This medication is approved for use in children. It has been studied in children as young as one year old. Talk to your child's healthcare provider about the risks and benefits of using Simulect in children.

Can Older Adults Use It?

In clinical trials, older adults tolerated Simulect as well as younger age groups. However, very few older adults were included in the clinical trials. As is generally the case, older adults may be more sensitive to the effects of this medicine. Therefore, older adults may need more careful monitoring during Simulect treatment.

Off-Label Uses for Simulect

On occasion, your healthcare provider may recommend this medicine for something other than kidney transplant rejection. This is known as an "off-label" use. Possible off-label uses for Simulect include:
  • Treatment of atopic dermatitis
  • Treatment of psoriasis
  • Treatment of graft versus host disease (a complication that may occur after a stem cell or bone marrow transplant)
  • Prevention of liver transplant rejection.

Simulect Medication Information

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