Rapamune Dosage

Rapamune comes in the form of a tablet and an oral solution (liquid). It is taken once a day. Factors that can affect your dose of Rapamune include your weight and your risk of transplant rejection, among other things. For people with a low risk of rejection, treatment usually starts with a one-time dose of 6 mg, followed by 2 mg each day after that.

An Introduction to Dosing With Rapamune

The dose of Rapamune® (sirolimus) your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • Your weight
  • Your blood levels of Rapamune
  • Your risk for transplant rejection
  • Other medical conditions you may have
  • Other medications you are taking.
  •  
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
 

Rapamune Dosage Guidelines

The usual Rapamune dose for preventing kidney transplant rejection in people with low rejection risk is a one-time initial dose of 6 mg (called a loading dose), followed by 2 mg each day thereafter (called the maintenance dose).
 
Children 13 years and older who weigh less than 40 kilograms (88 pounds) will be given a loading dose and daily dose based on their "body surface area," which is normally calculated using the child's height and weight.
 
The usual dosage of Rapamune for preventing kidney transplant rejection in people with high rejection risk is a loading dose of up to 15 mg, followed by a maintenance dose of 5 mg each day thereafter. People who weigh less than 40 kilograms (88 pounds) will be given a loading dose and daily dose based on their "body surface area," which is normally calculated using height and weight.
 
Your healthcare provider will measure your blood level of Rapamune using a simple blood test. He or she will adjust this amount, if needed, to keep your blood levels within the recommended range. Your dose may also be adjusted if you experience side effects or show signs of transplant rejection. The maximum recommended daily dose is Rapamune 40 mg per day.
 
People with liver disease will be given a lower maintenance dose. However, the loading dose will usually not change.
 
Rapamune is normally initially used in combination with cyclosporine (Gengraf®, Neoral®, Sandimmune®) and a corticosteroid (such as prednisone). However, cyclosporine will usually be slowly reduced and stopped 2 to 4 months after the transplant surgery in people with low risk for transplant rejection, and 12 months after surgery in people with high risk.
 

Rapamune Medication Information

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