Rapamune and Breastfeeding

There is some controversy surrounding the use of Rapamune (sirolimus) while breastfeeding. Some experts believe that this medication is not compatible with breastfeeding, while others believe it is safe, provided you monitor your nursing child for any side effects. Talk to your healthcare provider about your particular situation if you are thinking of breastfeeding while taking this drug.

Can Breastfeeding Women Take Rapamune?

Rapamune® (sirolimus) is a prescription medication approved to prevent transplant rejection (which occurs when the immune system attacks a newly transplanted organ) in people who have received a kidney transplant. It is unknown if Rapamune passes through breast milk in humans. The manufacturer recommends women choose either breastfeeding or Rapamune treatment -- but not both.

More Information About Rapamune and Breastfeeding

Rapamune has been shown to pass through the breast milk of rats in small amounts. The medicine has not been studied in lactating women. Based on the properties of the drug, it is expected to pass through human breast milk to some degree. However, due to the lack of information, it is unclear how much Rapamune would be found in breast milk. The drug's effects on a nursing infant, if any, are also unknown.
Rapamune is associated with potentially serious side effects, including increased risk for infection, lymphoma (cancer of the lymph nodes), and skin cancer. Because there is such little information available on Rapamune and breastfeeding, and because the medicine has the potential to cause these serious side effects, some experts recommend that women taking Rapamune not breastfeed.
If your healthcare provider recommends Rapamune while breastfeeding, be sure to observe your child for any possible problems, including but not limited to:
Do not hesitate to contact your child's healthcare provider if you have any concerns about your child's health.
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Rapamune Medication Information

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