Prograf is a type of immunosuppressant that is prescribed to prevent organ rejection in people who have had a liver, kidney, or heart transplant. It comes in the form of a capsule or an intravenous injection. Prograf works to prevent organ rejection by making the immune system less active, so it doesn't attack the new organ. Common side effects include diarrhea, tremors, and kidney problems.

What Is Prograf?

Prograf® (tacrolimus) is a prescription medication approved to prevent organ rejection in people who have received a kidney, liver, or heart transplant. It is used in combination with other medications. Prograf belongs to a group of medicines called immunosuppressants.
(Click Prograf Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Prograf is made by Astellas Pharma US, Inc.

How Does Prograf Work?

Transplant rejection occurs when the body's immune system recognizes the transplanted organ as a foreign material and attacks it. As an immunosuppressant medication, Prograf suppresses the immune system, making it less active. As a result, Prograf can help prevent transplant rejection from occurring.

When and How to Take It

Some general considerations to keep in mind during treatment with Prograf include the following:
  • This medication comes in the form of a capsule and an injection. The capsules are taken by mouth twice a day. The injection is given as a continuous, slow infusion into a vein (intravenously, or by IV).
  • You can take Prograf with food or on an empty stomach; however, it should always be taken exactly the same way, with the same amount of time between doses and meals each day.
  • Take your doses at the same time each day, 12 hours apart. This helps to keep an even level of the drug in your bloodstream.
  • Do not drink grapefruit juice or eat grapefruit while taking this medicine.
  • For the medication to work properly, it must be taken as prescribed. This medicine will not protect you from transplant rejection if you stop taking it.

Prograf Medication Information

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