Prograf Drug Interactions

P-Glycoprotein (Pgp) Inducers
P-glycoprotein is a natural protein that helps remove substances, such as medications, from the tissues in the body, so they can be excreted through the urine or feces. Pgp helps remove Prograf from the body. Certain medications known as Pgp inducers increase the activity of Pgp.
 
Taking Prograf with one of these Pgp inducers causes Prograf to be removed from the body too quickly, potentially making it less effective. Your healthcare provider may choose to monitor your Prograf blood levels more closely if you take it with a Pgp inducer, and adjust your dose as needed.
 
P-Glycoprotein (Pgp) Inhibitors
P-glycoprotein is a natural protein that helps remove substances, such as medications, from the tissues in the body, so they can be excreted through the urine or feces. Pgp helps remove Prograf from the body. Certain medications known as Pgp inhibitors decrease the activity of Pgp.
 
Taking Prograf with one of these Pgp inhibitors causes Prograf to be removed from the body more slowly, potentially increasing Prograf blood levels and increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely if you take Prograf with a Pgp inhibitor, and lower your dose if needed.
 
Pimecrolimus
It is recommended that people taking an immunosuppressant, including Prograf, not use pimecrolimus because of the increased risk for infections, lymphoma (cancer of the lymph nodes), and skin cancer.
 
Potassium-Sparing Diuretics
Combining potassium-sparing diuretics with Prograf increases the risk for high blood potassium levels (hyperkalemia). In general, these medicines should not be taken together.
 
Proton Pump Inhibitors (PPIs)
PPIs may increase Prograf blood levels, potentially increasing your risk for side effects. Talk to your healthcare provider before taking a PPI during Prograf treatment.

Prograf Medication Information

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