Prograf Drug Interactions

Combining Prograf with dabigatran could increase your dabigatran blood levels, and your risk for bleeding. Talk to your healthcare provider before combining these medicines. He or she may want to monitor you more closely, and possibly reduce your dabigatran dose.
Echinacea could decrease the effectiveness of Prograf. Do not take echinacea while taking Prograf, without first talking with your healthcare provider.
Grapefruit Juice
You should not drink grapefruit juice or eat grapefruit while taking Prograf. Grapefruit juice may increase the amount of Prograf in your body, potentially increasing your risk for side effects.
Combining leflunomide with Prograf may increase your risk for certain blood cell problems, such as abnormally low red blood cells, white blood cells, and platelets. Talk to your healthcare provider before taking these medicines together.
Live Vaccinations
You should not receive live vaccinations during Prograf treatment. Other vaccines may be less effective during Prograf treatment. Therefore, talk to your healthcare provider before you receive any vaccination or immunization while taking Prograf.
QT-Prolonging Medications
Prograf can cause QT prolongation (a certain change in the heart rhythm). Combining it with other medications that also cause this problem can increase the risk of a life-threatening arrhythmia. If such a combination is unavoidable, very careful monitoring of the heart rhythm using an electrocardiogram, blood electrolytes (since electrolyte imbalances increase the risk of an arrhythmia), and Prograf blood levels is recommended.
Combining Prograf with natalizumab may increase your risk for getting infections. In general, these medications should not be taken together.

Prograf Medication Information

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