Prograf Dosage

Dosage for Preventing Liver Transplant Rejection
The recommended initial dosage after a liver transplant in adults is 0.05 mg to 0.075 mg per kg twice a day (about 0.023 mg to 0.034 mg per pound), started at least six hours after the transplant surgery. People with kidney problems or those who develop severe liver problems after their transplant surgery may need lower doses of Prograf.
 
The recommended initial dosage after a liver transplant in children is 0.075 mg to 0.1 mg per kg twice a day (about 0.034 mg to 0.045 mg per pound).
 
Dosage for Preventing Heart Transplant Rejection
The recommended initial Prograf dosage after a heart transplant is 0.0375 mg per kg twice a day (about 0.017 mg per pound), started at least six hours after the transplant surgery. People with kidney problems or severe liver disease may need lower doses of Prograf.
 

Dosing Guidelines for Prograf Injections

If you are unable to take Prograf by mouth after your surgery, you may be given Prograf injections. The recommended initial dose of Prograf injections is 0.01 mg per kg each day after a heart transplant (0.0045 mg per pound) and 0.03 mg to 0.05 mg per kg each day after a liver or kidney transplant (0.014 mg to 0.023 mg per pound). Injectable Prograf is given as a continuous intravenous injection (an IV injection or injection into the vein).
 
You will be switched over to oral Prograf capsules as soon as possible, usually within two to three days after your surgery. Your first oral Prograf dosage will normally be given 8 to 12 hours after the IV injection is stopped.
 

Dose Adjustments

Your healthcare provider will monitor your blood levels of Prograf and, if needed, adjust your dosage to keep your blood levels within the recommended range. Your dosage may also be adjusted if you are experiencing Prograf side effects or showing signs of transplant rejection.
 

Prograf Medication Information

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