Prograf and Neurotoxicity

Prograf® (tacrolimus) is a medicine prescribed to prevent organ rejection in people who have had a liver, heart, or kidney transplant. Although it can be an effective treatment for many people, there are some complications to be aware of with this medicine. For example, Prograf can cause neurotoxicity, or problems with the nervous system, particularly when high doses of this medicine are used.
Some of the possible problems that may occur with neurotoxicity include tremors, headaches, and numbness or tingling of the skin. However, severe problems can also occur and may include seizures, coma, and encephalopathy (a disease of the brain that causes altered brain function).
(For more information on how this drug can cause neurotoxicity and other potentially serious complications, click Prograf Warnings and Precautions. A list of who should not take this drug is also provided.)
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