Orthoclone OKT3 and Breastfeeding

The manufacturer of Orthoclone OKT3 (muromonab-CD3) does not advise women to use this medication while nursing, as it is unknown if the drug passes through human breast milk or if it would harm a nursing infant. Because this drug is associated with potentially dangerous reactions or infections, it may be best for women to avoid breastfeeding when receiving Orthoclone OKT3.

Can Breastfeeding Women Receive Orthoclone OKT3?

Orthoclone OKT®3 (muromonab-CD3) is a prescription medication approved to treat kidney transplant rejection. It is also used to treat liver and heart transplant rejection after steroid medications have been tried but failed.
 
At this time, it is unknown if Orthoclone OKT3 passes through breast milk. The manufacturer does not recommend that women use this drug while breastfeeding, due to the unknown risks.
 

More Information on Orthoclone OKT3 and Breastfeeding

Orthoclone OKT3 has not been studied in breastfeeding women. Therefore, it is unknown whether the medicine passes through breast milk.
 
However, Orthoclone OKT3 is a synthetic (laboratory-made) form of immunoglobulin G (IgG) antibody, a protein made by the immune system. Natural IgG is known to pass through breast milk, and it is likely that at least some Orthoclone OKT3 would also pass through breast milk. However, very little IgG is absorbed from a nursing infant's digestive tract into the infant's bloodstream. It is unknown whether the same would be true for Orthoclone OKT3.
 
Orthoclone OKT3 lowers the activity of the immune system, and is associated with potentially serious side effects, including a risk for infections. Because of the potential for these side effects in a nursing infant, it is probably best to avoid breastfeeding while receiving this medication.
 
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Orthoclone OKT3 Drug Information

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