Neoral Drug Interactions

P-Glycoprotein (Pgp) Inhibitors
P-glycoprotein is a natural protein that helps remove substances, such as medications, from the tissues in the body, so they can be excreted through the urine or feces. Pgp helps remove Neoral from the body. Certain medications known as Pgp inhibitors decrease the activity of Pgp.
 
Taking Neoral with one of these Pgp inhibitors causes Neoral to be removed from the body more slowly, potentially increasing Neoral blood levels and increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely if you take Neoral with a Pgp inhibitor, and lower your dose if needed.
 
Pimecrolimus
Taking Neoral with pimecrolimus may increase your risk for potentially serious Neoral side effects, including infections and skin cancer. Although the risk for these serious side effects is rare, it is typically recommended that pimecrolimus not be used with medicines that weaken the immune system, including Neoral.
 
Potassium-Sparing Diuretics
Combining potassium-sparing diuretics with Neoral increases the risk for high blood potassium levels (hyperkalemia). In general, these medicines should not be taken together.
 
Silodosin
Neoral may increase the amount of silodosin in your blood, increasing your risk for side effects. It is generally recommended that these medicines not be used together.
 
Statin Medications
Neoral may increase blood levels of statin medicines, possibly increasing the risk for serious statin side effects. Neoral should not be taken with simvastatin or pitavastatin. Other statins may require a dosage reduction if taken with Neoral.
 
Tacrolimus
Taking Neoral with tacrolimus may increase your risk for potentially serious Neoral side effects, including infections and skin cancer. Although the risk for these serious side effects is rare, it is generally recommended that tacrolimus not be used with medicines that weaken the immune system, including Neoral.
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Neoral Medication Information

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