Neoral Drug Interactions

CYP 3A4 Inhibitor Medications
The liver breaks down Neoral using enzymes known as CYP 3A4 enzymes. Some medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining Neoral with one of these CYP 3A4 inhibitors may increase the level of Neoral in your body, potentially increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely if you take Neoral with a CYP 3A4 inhibitor.
Combining Neoral with dabigatran could increase your dabigatran blood levels, and your risk for bleeding. Talk to your healthcare provider before combining these medicines. He or she may want to monitor you more closely, or give you a lower dabigatran dose.
Neoral may increase the level of digoxin in your bloodstream, which could increase your risk for serious digoxin side effects. Your healthcare provider will need to monitor you closely if you take these medicines together.
Echinacea could decrease the effectiveness of Neoral. Do not take echinacea while taking Neoral, without first talking with your healthcare provider.
Combining Neoral with fentanyl could cause your fentanyl blood levels to increase to potentially unsafe levels. If your fentanyl levels become too high, you may experience serious fentanyl side effects, including dangerously slow and shallow breathing. If you take these medicines together, your healthcare provider should monitor you closely for fentanyl side effects, especially when you first start taking Neoral.
Grapefruit Juice
Do not consume grapefruit juice during Neoral treatment. Grapefruit juice may increase the amount of Neoral in your body, potentially increasing your risk for serious side effects.
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Neoral Medication Information

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