Mycophenolate Side Effects

Other Possible Side Effects

Mycophenolate has been studied thoroughly in clinical trials. In these studies, the side effects that occurred in a group of people taking mycophenolate were carefully documented and compared to those that occurred in a similar group of people taking a different anti-rejection medication. As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the other medication.
 
In these studies, the most common side effects of mycophenolate included:
 
  • High blood pressure (hypertension) -- in up to 77.5 percent of people
  • Pain, including pain after the transplant surgery -- up to 75.8 percent
  • Swelling (edema) of the legs, ankles, and feet -- up to 64 percent
  • Abdominal pain (stomach pain) -- up to 62.5 percent
  • Nausea -- up to 54.5 percent
  • Headache -- up to 54.3 percent
  • Fever -- up to 52.3 percent
  • Insomnia -- up to 52.3 percent
  • Diarrhea -- up to 51.3 percent
  • Constipation -- in up to 38 percent of people
  • Urinary tract infection (UTI) -- up to 29.1 percent
  • Vomiting -- up to 23 percent
  • Heartburn or indigestion -- up to 22.5 percent.
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Other common reactions, occurring in 3 to 46.7 percent of people, included but were not limited to:
 
  • Infections, including potentially serious infections
  • Increased blood glucose (blood sugar)
  • Back pain
  • Muscle and joint pain
  • Lack of energy and weakness
  • Gas
  • Bloating
  • Decrease in blood cell counts, including white blood cells, red blood cells, and platelets
  • Increased cholesterol (fats or lipids)
  • Low blood electrolytes, such as potassium, calcium, and magnesium
  • Sore throat
  • Cold sores
  • Shingles
  • Sinus congestion
  • Thrush (a fungal infection of the mouth)
  • Chest pain
  • Rash
  • Bruises
  • Breathing problems, including shortness of breath and coughing
  • Tremor
  • Decreased blood pressure
  • Abnormal kidney function
  • Dizziness
  • Anxiety
  • Depression
  • Edema (swelling of body tissues)
  • Fast heart rate (tachycardia)
  • Decreased appetite
  • Heart disease
  • Abnormal liver function tests
  • Heartburn or indigestion
  • Tingling, pricking, or numbing sensations of the skin
  • Blurred vision
  • Acne
  • Itching
  • Cysts
  • Excessive, coarse, dark hair growth
  • Fat deposits on the face and back, causing a round face and a fatty hump on the back of the neck
  • Overgrowth of gum tissue
  • Dehydration
  • Pain while urinating, difficulty urinating, and blood in the urine
  • Weight gain.
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Mycophenolate Drug Information

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