How Does It Work?

Mycophenolate works by blocking the action of an enzyme in the body known as inosine monophosphate dehydrogenase (IMPDH). This enzyme is needed for T- and B-lymphocytes (cells in the immune system) to multiply.
Transplant rejection occurs when the immune system, which is responsible for fighting infections, sees the transplanted organ as foreign and attacks it. By preventing T- and B-lymphocytes from multiplying, mycophenolate decreases the activity of the immune system and decreases the chance that transplant rejection will occur.

When and How to Take Mycophenolate

Some general considerations to keep in mind during treatment with mycophenolate include the following:
  • This medication comes as a delayed-release tablet, a regular tablet, a capsule, an oral liquid solution, and an intravenous (IV) injection. The tablets, capsules, and liquid solution are usually taken by mouth twice a day. The injection is given as an infusion into a vein twice a day.
  • You should take this medicine on an empty stomach, one hour before or two hours after a meal. Certain people who are stable on treatment may be able to take mycophenolate with food, depending on the form taken, and only with a healthcare provider's approval.
  • Try to take your doses at the same time each day to keep an even level of medicine in your bloodstream.
  • Mycophenolate tablets and capsules must be swallowed whole. Do not crush, cut, or chew the tablets, or open or crush the capsules.
  • Shake the liquid suspension well before use. Measure your dose with a marked oral syringe or medicine cup. Do not use regular household spoons, as they are not accurate enough to measure liquid medicines. Your pharmacist can give you an appropriate measuring device if you need one.
  • For this drug to work properly, it must be taken as prescribed. Do not stop taking this medicine or change to another brand of mycophenolate without first talking to your healthcare provider.

Mycophenolate Drug Information

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