Drug Interactions With Mycophenolate
Mycophenolate may make oral contraceptives less effective. If you are a woman of childbearing potential, you should talk to your healthcare provider about the best birth control option for you during mycophenolate treatment.
Taking mycophenolate with pimecrolimus could increase your risk for potentially serious side effects, including infection, lymphoma (cancer of the lymph nodes), and skin cancer. Although the risk for these side effects is generally low, it is recommended that pimecrolimus cream not be used with medicines that weaken the immune system, including mycophenolate.
Taking probenecid with mycophenolate may increase the amount of mycophenolate in your blood, possibly increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely if you take these medicines together, and decrease your mycophenolate dose if needed.
Proton Pump Inhibitors (PPIs)
Proton pump inhibitors may decrease the amount of mycophenolate absorbed into your body, potentially making it less effective. If you take mycophenolate, be sure to talk to your healthcare provider before taking a PPI.
Rifampin may decrease the amount of mycophenolate in the blood, potentially making it less effective. Do not combine these medicines without first talking to your healthcare provider. If they are taken together, higher mycophenolate doses may be needed.
Sevelamer is thought to bind to mycophenolate in the gut, decreasing the amount of medicine absorbed into the body. These drugs should not be taken together, if at all possible. If they must be used together, sevelamer should be taken two hours after mycophenolate.