Kidneys Home > Votrient

If you have advanced kidney cancer or soft tissue sarcoma, your healthcare provider may prescribe Votrient. This medication comes in the form of a tablet and is taken once a day on an empty stomach. It works by blocking certain enzymes in the body, which helps to slow down the growth of cancer cells. Common side effects include diarrhea, nausea, and changes in hair color.

What Is Votrient?

Votrient® (pazopanib) is a prescription medication that belongs to a group of medicines called tyrosine kinase inhibitors. It is approved for the treatment of the following types of cancer:
  • Advanced renal cell carcinoma (kidney cancer)
  • Soft tissue sarcoma, a cancer of the soft tissues of the body, such as muscles and fat.
(Click Votrient Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Votrient is made by GlaxoSmithKline.

How Does It Work?

Votrient works by blocking an enzyme in the body known as tyrosine kinase. This enzyme tells cancer cells to grow and divide. By blocking tyrosine kinase, Votrient may slow down the growth of cancer cells.

Clinical Effects of Votrient

In clinical studies, Votrient improved "progression-free survival" (PFS), which is the period of time cancer does not get worse. In one study, people with advanced kidney cancer who took Votrient had an average of 9.2 months of PFS, compared with 4.2 months in people taking a placebo (a "sugar pill" that does not contain any active ingredients). In another study, people with soft tissue cancer experienced an average of 4.6 months of PFS, while people given a placebo had 1.6 months of PFS.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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