Kidneys Home > Simulect Uses

If you have received a kidney transplant, a healthcare provider may prescribe Simulect to help prevent transplant rejection. This medication works by binding to a specific antigen on certain types of white blood cells, preventing them from attacking and destroying the newly transplanted kidney. Simulect is approved for use in adults and children as young as one year old.

What Is Simulect Used For?

Simulect® (basiliximab) is a prescription medication approved to prevent organ rejection in people who are receiving a kidney transplant. It is used in combination with other anti-rejection medications, including cyclosporine (Gengraf®, Neoral®, Sandimmune®) and a corticosteroid.
A kidney transplant is a surgical procedure in which a healthy kidney (or donor kidney) is placed into someone who has kidney failure. Donated kidneys can come from a living donor or a nonliving donor (someone who has recently died). After the transplant, the healthy kidney takes over the function of the failing kidney. The failed kidney may or may not be removed during the surgery.
After a kidney transplant, the immune system, which is responsible for protecting the body from invaders, recognizes that the newly transplanted kidney is not a natural part of the body and attacks it. This is called transplant rejection. It is important to try to prevent transplant rejection, as it can cause the new kidney to fail. Therefore, people who receive kidney or other organ transplants are given medications to help prevent rejection.
Simulect is given to help prevent acute kidney rejection, which is rejection that occurs within the first six months of receiving a donor kidney. The medication is given as two doses, four days apart.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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