Kidneys Home > Rapamune

Rapamune is a medication used to prevent organ rejection after a kidney transplant. As an immunosuppressant, it works by affecting the body's immune system. The medication comes in two forms (a tablet and a liquid) and is taken once a day. Commonly reported side effects include swelling, headache, and high blood pressure.

What Is Rapamune?

Rapamune® (sirolimus) is a prescription medication that belongs to a class of drugs called immunosuppressants. It is approved for use in combination with other medicines to prevent organ rejection after a kidney transplant.
 
(Click Rapamune Uses for more information on this topic, including possible off-label uses.)
 

Who Makes This Medication?

Rapamune is made by Pfizer, Inc., and distributed by Wyeth Pharmaceuticals, Inc., a subsidiary of Pfizer, Inc.
 

How Does It Work?

Transplant rejection occurs when the immune system recognizes a transplanted organ is not a normal part of the body and tries to get rid of it. Rapamune is an "immunosuppressant" medication. It works by decreasing the activity of the immune system, thus helping to prevent transplant rejection from occurring.
 

Clinical Effects of Rapamune

Rapamune has been shown to reduce the risk for kidney transplant rejection in clinical studies. In one study, 19 percent of people given Rapamune experienced a rejection episode within six months of their transplantation surgery, compared with 41 percent of people given a placebo (a "sugar pill" with no active ingredients).
 
In another study, 11 percent of those taking Rapamune had transplant rejection within six months, compared with 29 percent of people taking a different anti-rejection medicine, azathioprine (Imuran®). In both studies, Rapamune was given in combination with cyclosporine and a corticosteroid medicine.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation
Advertisement


Topics & Medications

Quicklinks

Related Channels

eMedTV Links
Copyright © 2006-2019 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.