Kidneys Home > Rapamune Overdose

If a person overdoses on Rapamune (sirolimus), the symptoms would likely be similar to the usual side effects that have been reported with the drug. Some of these effects include high blood pressure, edema, and kidney problems. Treating this type of overdose may involve "pumping the stomach," administering activated charcoal, or providing supportive care.

Can You Take Too Much Rapamune?

Rapamune® (sirolimus) is a prescription medication approved to prevent rejection in people who have received a kidney transplant. It is used in combination with other medicines. As with any medicine, it is possible to take too much Rapamune. The specific effects of an overdose would likely vary, depending on a number of factors, including the Rapamune dosage and whether it was taken with any other medications or substances.

Effects of a Rapamune Overdose

There is very little information available on what to expect with an overdose of Rapamune. Based on the limited information that is available, symptoms are expected to be similar to the usual Rapamune side effects. Such side effects include but are not limited to:

Treatment Options

If the overdose was recent, a healthcare provider may administer activated charcoal or "pump the stomach" to help reduce the amount of the medication that is absorbed into the bloodstream. Dialysis is not expected to help remove Rapamune from the bloodstream.
Treatment will also involve supportive care, which consists of treating symptoms that occur as a result of the overdose. For example, high blood pressure, if it occurs, may be treated with blood pressure medicines.
It is important that you seek medical attention immediately if you believe that you or someone else may have taken an overdose of Rapamune.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation

Topics & Medications


Related Channels

eMedTV Links
Copyright © 2006-2019 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.