Kidneys Home > Prograf and Nephrotic Syndrome
Although Prograf is not approved to treat nephrotic syndrome, it is sometimes prescribed for this "off-label" use. This condition occurs due to kidney damage and can result in several symptoms, such as high levels of protein in the urine, high cholesterol levels, and swelling. Studies have shown that Prograf can help relieve symptoms of these conditions in both adults and children.
An Overview of Nephrotic Syndrome and PrografNephrotic syndrome is a medical term used to describe a group of symptoms that can occur in some people with kidney disease. It is not a disease itself, but instead occurs as a result of kidney damage due to various conditions.
More Information About Nephrotic SyndromeNephrotic syndrome occurs when the glomeruli (tiny structures in the kidneys that filter waste products from the blood) become damaged. This damage allows large amounts of proteins to leak from the blood into the urine, resulting in abnormally high levels of protein in the urine. Other symptoms of nephrotic syndrome include:
- Low levels of protein in the blood
- Swelling (edema), especially of the face, hands, feet, and ankles
- High cholesterol levels
- Foamy urine (caused by the excess protein).
- Minimal change disease (the most common cause of nephrotic syndrome in children)
- Membranous nephropathy (a kidney disorder characterized by thickening of the structures of the kidneys)
- Systemic lupus erythematosus (SLE)
- Hepatitis B or hepatitis C infection
- Certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs).