Kidneys Home > Orthoclone OKT3 Dosage

Your age and how you respond to the medication are some of the factors your healthcare provider will take into consideration when determining your dosage of Orthoclone OKT3. This prescription medication is given as an injection into a vein (an intravenous, or IV, injection) for 10 to 14 days. It is administered by a healthcare provider in a healthcare setting.

An Introduction to Dosing With Orthoclone OKT3

The dose of Orthoclone OKT®3 (muromonab-CD3) your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • Your age
  • Weight (in children)
  • Levels of the medication in your blood
  • How you respond to the medication.
 
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
 

Recommended Orthoclone OKT3 Dosage

The usual dose of Orthoclone OKT3 for the treatment of transplant rejection in adults is 5 mg a day for 10 to 14 days. The usual initial dosage for children who weigh 30 kg or less (66 pounds or less) is 2.5 mg per day. Children who weigh more than 30 kg are normally given the adult amount.
 
Doses may be increased, usually by 2.5 mg a day, based on response and Orthoclone OKT3 blood levels. It is generally recommended that blood levels be at least 800 nanograms per milliliter (ng per mL), especially in children.
 
Your healthcare provider may give you a corticosteroid medicine, such as methylprednisolone (Depo-Medrol®, Medrol®), one to four hours before your first Orthoclone OKT3 dosage. You may also be given acetaminophen (Tylenol®) and an antihistamine, such as diphenhydramine (Benadryl® and others), with each dose. These medications are used to reduce your risk of developing a potentially serious reaction to Orthoclone OKT3.
 
In addition, your healthcare provider may monitor your weight and obtain certain tests, such as an x-ray and blood tests, before you begin treatment. These tests are done to make sure you do not have certain medical problems that could increase your risk for complications.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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