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Nexavar Drug Interactions ExplainedThe following sections explain in detail the potentially negative interactions that can occur when Nexavar is combined with any of the drugs listed above.
Taking acetaminophen during Nexavar treatment may increase your risk for liver damage. It is generally recommended that people who take Nexavar limit their use of acetaminophen. Talk to your healthcare provider about how much acetaminophen you can safely take each day.
People who have a certain type of lung cancer and are being treated with carboplatin and paclitaxel should not take Nexavar due to the possible increased risk of death when all three medications are taken together.
CYP 3A4 Inducer Medications
The liver breaks down Nexavar using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining Nexavar with one of these drugs may decrease the level of Nexavar in your body, potentially making it less effective. It is generally recommended that Nexavar not be combined with strong CYP 3A4 inducers.
CYP 3A4 Inhibitor Medications
The liver breaks down Nexavar using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Nexavar with one of these drugs may increase the level of Nexavar in your body, potentially increasing your risk for side effects.
Taking denosumab with Nexavar could increase your risk for potentially serious infections. Talk to your healthcare provider before taking these drugs together. Also, contact your healthcare provider if you develop any symptoms of an infection, such as:
- Aches and pains