Kidneys Home > Neoral Drug Interactions

Live Vaccinations
You should not receive live vaccinations during Neoral treatment. Other vaccines may be less effective during Neoral treatment. Therefore, talk to your healthcare provider before you receive any vaccination or immunization while taking Neoral.
 
Methotrexate
People taking Neoral for psoriasis should not combine Neoral with methotrexate, due to the increased risk for skin cancer.
 
Methylprednisolone
There have reports of seizures in people taking Neoral, especially when used in combination with methylprednisolone. There have also been reports of encephalopathy, a medical term for a disease of the brain that causes altered brain function. Seek immediate medical care if you experience problems of encephalopathy, such as:
 
  • Confusion
  • Vision changes
  • Muscle weakness
  • Problems with movement
  • Seizures.
 
Natalizumab
Combining Neoral with natalizumab may increase your risk for potentially serious infections. In general, these medications should not be taken together.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Taking Neoral with an NSAID may increase your risk for kidney problems. Your healthcare provider may need to monitor your kidneys more closely if you start taking an NSAID, or have an increase in your NSAID dose, during Neoral treatment.
 
Orlistat
Orlistat may decrease the amount of Neoral absorbed from your gut into your body, which could make the medicine less effective. You should not take orlistat while taking Neoral.
 
P-Glycoprotein (Pgp) Inducers
P-glycoprotein is a natural protein that helps remove substances, such as medications, from the tissues in the body, so they can be excreted through the urine or feces. Pgp helps remove Neoral from the body. Certain medications known as Pgp inducers increase the activity of Pgp.
 
Taking Neoral with one of these Pgp inducers causes Neoral to be removed from the body too quickly, potentially making it less effective. Your healthcare provider may choose to monitor your Neoral blood levels more closely if you take it with a Pgp inducer, and adjust your dose as needed.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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