Kidneys Home > Neoral Dosage

Your healthcare provider will take several factors into consideration when determining a suitable dosage of Neoral for your particular situation. Some of these factors include your weight, the reason you are taking this medication, and other medications you are taking. The initial dose is usually 2.5 mg per kg of body weight each day, which is divided into twice-daily dosing. Your healthcare provider can gradually adjust this amount.

An Introduction to Dosing With Neoral

The dosage of Neoral® (cyclosporine) your healthcare provider recommends will vary, depending on a number of factors, including:
  • The reason you are taking the medicine
  • How you respond to it
  • Your weight
  • Your blood levels of Neoral 
  • Other medications you are taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Neoral Dosage for Preventing a Transplant Rejection

The initial dose of Neoral to prevent an organ transplant rejection varies from person to person. Your healthcare provider will recommend an initial amount based on your weight, your transplant organ, and any other anti-rejection medications you are given. Treatment with Neoral is usually started 4 to 12 hours before transplant surgery, right after the transplant, or a few days after the transplant (usually in the case of a kidney transplant).
Your healthcare provider will monitor you closely and adjust your initial dosage based on your Neoral blood levels, side effects you experience, and whether there is any evidence of transplant rejection. The goal is to find the best possible dosage for you that prevents transplant rejection, while avoiding potentially serious or bothersome side effects. If you require long-term treatment, your healthcare provider will gradually adjust the amount to the lowest effective Neoral dosage.
The initial dosage of Neoral for people who are switching from original cyclosporine (Sandimmune®) will be the same as the previously used daily cyclosporine dose. Neoral blood levels will be checked once or twice a week, and the dosage will be adjusted until the desired blood level is obtained. Dosage adjustments may also be needed if potentially serious side effects occur.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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