Myfortic is an immunosuppressant used to prevent the body from rejecting a newly transplanted kidney. It comes in the form of a delayed-release capsule and is taken twice a day. This prescription medication is taken in combination with cyclosporine and a corticosteroid. Side effects may include nausea, diarrhea, and urinary tract infection, among others.
Mycophenolate, the active ingredient in Myfortic, is also available as mycophenolate mofetil in CellCept®. Myfortic and CellCept are similar medicines. However, they are absorbed differently by the body, and therefore are not directly interchangeable. Do not switch from one form of mycophenolate to another without first talking to your healthcare provider.
Myfortic is manufactured by Novartis Pharma Stein AG for Novartis Pharmaceuticals Corporation.
How Does Myfortic Work?
Myfortic works by blocking the action of an enzyme in the body known as inosine monophosphate dehydrogenase (IMPDH). This enzyme is needed for T- and B-lymphocytes (cells that are part of the immune system) to multiply.
Transplant rejection occurs when the immune system, which is responsible for fighting infections, sees the transplanted organ as foreign material and attacks it. By preventing T- and B-lymphocytes from multiplying, Myfortic decreases the activity of the immune system, thus decreasing the risk of transplant rejection.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Myfortic [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation;2013 September.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed September 23, 2011.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed September 23, 2011.
National Library of Medicine (US). Hazardous Substances Data Bank (HSDB). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB. Accessed September 23, 2011.
eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind.
Site users seeking medical advice about their specific situation should consult with their own physician. Click