Kidneys Home > What Is Everolimus Used For?
A healthcare provider may prescribe everolimus for several purposes. This medicine is approved for treating certain cancers and tumors, and can also be used in low doses to prevent organ rejection following a kidney or liver transplant. However, there are also some possible "off-label," or unapproved, uses for everolimus. For example, some of the off-label uses for this drug include treating rheumatoid arthritis and advanced breast cancer.
What Is Everolimus Used For?Everolimus (Afinitor®, Zortress®) is a prescription medication belonging to a group of drugs called kinase inhibitors. It is also considered an immunosuppressant medication, which means it lowers the activity of the immune system.
- Advanced neuroendocrine tumors of pancreatic origin (PNET), a rare type of cancer of the pancreas, when it cannot be treated with surgery. PNET is sometimes called pancreatic islet cell cancer.
- Advanced renal cell carcinoma (RCC), a type of kidney cancer, which has not been successfully treated with sunitinib (Sutent®) or sorafenib (Nexavar®). Everolimus may help extend the length of time RCC remains stable and does not progress.
- Subependymal giant cell astrocytoma (SEGA), a type of brain tumor that occurs in people with a rare genetic condition known as tuberous sclerosis. Everolimus is approved for the treatment of SEGA that requires treatment but cannot be cured with surgery.
- Renal angiomyolipoma, a type of kidney tumor, in people with tuberous sclerosis who do not require immediate surgery
- Certain types of advanced breast cancer in postmenopausal women who have not responded to certain other medications.