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Everolimus Dosing for Brain Tumors

The initial everolimus dose for treating subependymal giant cell astrocytoma (SEGA), a rare type of brain tumor, will vary based on your "body surface area," which is normally calculated using your height and weight.
 
Your dosage will be adjusted, by no more than 2.5 mg every two weeks (for the regular tablets) or no more than 2 mg every two weeks (for the Disperz tablets), based on the level of everolimus in your blood. The typical everolimus blood level for the treatment of SEGA is 5 to 10 nanograms per milliliter (ng per mL). Higher or lower levels may be necessary in some people to obtain adequate tumor response, or to minimize side effects. The maximum recommended everolimus blood level is 15 ng per mL.
 
If the lowest available strength (2 mg) is too high, then everolimus can be given every other day to help achieve the proper dosage.
 

Everolimus Dosing for Kidney Tumors

The recommended dosage of everolimus for the treatment of renal angiomyolipoma in people with tuberous sclerosis is 10 mg once a day. People who develop serious or intolerable side effects may need to temporarily stop taking the medicine, or take a lower dose (usually 5 mg a day).
 
Lower doses are normally given to people with liver disease. The recommended dosage for people with mild liver disease is 7.5 mg a day. The dose may be reduced to 5 mg a day if 7.5 mg is not tolerated.
 
The recommended dosage for people with moderate liver disease is 5 mg daily. The dose may be reduced to 2.5 mg a day if 5 mg is not tolerated.
 
People with severe liver disease should be given no more than 2.5 mg of everolimus a day.
 
Higher or lower amounts may be used in people taking certain medications known to interact with everolimus.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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