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Nausea, vomiting, constipation, and fatigue are the most common side effects of Epogen. These side effects are typically minor and, in most cases, do not require medical attention. Certain Epogen side effects are potentially serious, however, and should be reported to a healthcare provider immediately, including high blood pressure, seizures, allergic reactions, or an irregular heart rhythm.

An Introduction to Epogen Side Effects

As with any medicine, side effects are possible with Epogen® (epoetin alfa); however, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Epogen. Your healthcare provider can discuss a more complete list of Epogen side effects with you.)

Common Epogen Side Effects

Epogen has been studied thoroughly in clinical trials, in which side effects are carefully documented. In these studies, the most common side effects of Epogen included:
  • Nausea -- in up to 58 percent of people
  • Constipation -- up to 53 percent
  • Fatigue -- up to 44 percent
  • Vomiting -- up to 29 percent
  • Fever -- up to 29 percent
  • Irritation, redness, or pain at the injection site -- up to 29 percent
  • Infection -- up to 27 percent.
Other common Epogen side effects (occurring in 11 to 24 percent of people) included:
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Last reviewed by: Kristi Monson, PharmD;
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