What Is Everolimus Used For?

A healthcare provider may prescribe everolimus for several purposes. This medicine is approved for treating certain cancers and tumors, and can also be used in low doses to prevent organ rejection following a kidney or liver transplant. However, there are also some possible "off-label," or unapproved, uses for everolimus. For example, some of the off-label uses for this drug include treating rheumatoid arthritis and advanced breast cancer.

What Is Everolimus Used For?

Everolimus (Afinitor®, Zortress®) is a prescription medication belonging to a group of drugs called kinase inhibitors. It is also considered an immunosuppressant medication, which means it lowers the activity of the immune system.
Everolimus comes in a low- and high-dose product. High-dose everolimus (Afinitor) is approved to treat the following conditions:
  • Advanced renal cell carcinoma (RCC), a type of kidney cancer, which has not been successfully treated with sunitinib (Sutent®) or sorafenib (Nexavar®). Everolimus may help extend the length of time RCC remains stable and does not progress.
  • Subependymal giant cell astrocytoma (SEGA), a type of brain tumor that occurs in people with a rare genetic condition known as tuberous sclerosis. Everolimus is approved for the treatment of SEGA that requires treatment but cannot be cured with surgery.


  • Renal angiomyolipoma, a type of kidney tumor, in people with tuberous sclerosis who do not require immediate surgery


  • Certain types of advanced breast cancer in postmenopausal women who have not responded to certain other medications. 
In lower doses, everolimus (Zortress) is approved to prevent organ rejection in certain people after a kidney or liver transplant. Transplant rejection occurs when the body's immune system mistakes the transplanted organ as a potentially harmful foreign substance and attacks it. When used for the prevention organ rejection, everolimus is always used in combination with other anti-rejection medications. 
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Everolimus Drug Information

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