Everolimus Side Effects

Some of the most commonly reported side effects of everolimus include mouth sores, a rash, and diarrhea. While reactions such as these are typically minor, there are some potentially serious complications that require immediate medical treatment. Contact your healthcare provider right away if you develop breathing problems, unusual bleeding or bruising, or any signs of an infection.

An Introduction to Side Effects of Everolimus

Just like any medicine, everolimus (Afinitor®, Zortress®) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with everolimus. Your healthcare provider can discuss a more complete list with you.)

Serious Everolimus Side Effects

Some side effects of this drug are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Breathing problems, such as:
    • Wheezing
    • Shortness of breath
    • Chest pain
    • A new or worse cough
  • Sores or ulcers in your mouth or around your lips
  • Unusual bleeding or bruising
  • Signs of infection, such as:
    • High fever
    • Chills
    • Aches and pains
  • Wounds, sores, or surgical incision sites that:


    • Do not heal
    • Are red, swollen, or full of pus or fluid
    • Otherwise seem infected


  • Swelling in the body, such as the arms, legs, ankles, or feet
  • Swollen glands in the neck, armpits, or groin
  • Any skin changes, such as discoloration, sores, or lumps
  • Pain in your groin, abdomen (stomach), lower back, or side
  • Muscle weakness or cramps
  • An irregular, rapid, or forcefully beating heart
  • Problems with urination, such as:
    • Painful urination
    • Less frequent urination
    • An inability to urinate
    • Foamy or dark-colored urine
    • Blood in the urine
  • Signs of liver problems, such as:
    • Dark urine
    • Loss of appetite
    • Fatigue or excessive tiredness
    • Pain in the upper-right area of the abdomen (stomach)
    • Yellowing of the skin or whites of the eyes (jaundice)
  • Seizures
  • Mood or personality changes, such as:
  • Signs of anemia (low red blood cells), such as:
    • Fatigue
    • Pale skin
    • Dizziness
    • Shortness of breath
    • Frequent urination
    • Increased thirst
    • Blurred vision
    • Fatigue
    • Weight loss
  • Signs of an allergic reaction, such as:


    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth or throat
    • Wheezing
    • Difficulty breathing or swallowing.
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Everolimus Drug Information

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