Everolimus Dosage

Everolimus Dosing for Breast Cancer

The recommended dose of everolimus for advanced breast cancer is 10 mg once daily. For this use, everolimus should be combined with exemestane (Aromasin®).
 
If serious or intolerable side effects occur, the drug may need to be stopped or reduced to 5 mg daily.
 
The recommended dosage for people with mild liver disease is 7.5 mg a day. The dose may be reduced to 5 mg a day if 7.5 mg is not tolerated. The recommended dosage for people with moderate liver disease is 5 mg daily. The dose may be reduced to 2.5 mg a day if 5 mg is not tolerated. People with severe liver disease should be given no more than 2.5 mg of everolimus a day.
 
Higher or lower amounts may be used in people taking certain medications known to interact with everolimus (see Drug Interactions With Everolimus for more information).
  

Everolimus Dosing for Preventing Kidney Transplant Rejection

The recommended dosage to prevent kidney transplant rejection is usually everolimus 0.75 mg twice a day, taken in combination with two other anti-rejection medications -- cyclosporine (Gengraf®, Neoral®, Sandimmune®) and prednisone. The medications will be started as soon as possible after your kidney transplant. People with moderate liver disease are typically started on lower everolimus doses.
 
People who take everolimus after a kidney transplant will receive lower doses of cyclosporine. This is to decrease the risk of kidney damage that can occur when standard cyclosporine transplant-rejection doses are used with everolimus.
 
Your healthcare provider may need to adjust your initial amount, no more often than every four to five days, based on your everolimus blood levels. The recommended everolimus blood level for preventing kidney transplant rejection is 3 to 8 ng per mL.
 
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Everolimus Drug Information

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