Drug Interactions With Everolimus

P-Glycoprotein (Pgp) Inducers
P-glycoprotein is a natural protein that helps remove substances, such as medications, out of body tissues, so they can be excreted through the urine or feces. Pgp helps remove everolimus from the body. Certain other medications known as Pgp inducers increase the activity of Pgp.
 
Taking everolimus with one of these Pgp inducers causes everolimus to be removed from the body too quickly, potentially making it less effective. Your healthcare provider may choose to monitor your everolimus blood levels more closely if you take it with a Pgp inducer, and adjust your dose as needed.
 
P-Glycoprotein (Pgp) Inhibitors
P-glycoprotein is a natural protein that helps remove substances, such as medications, out of the body tissues, so they can be excreted through the urine or feces. Pgp helps remove everolimus from the body. Certain other medications known as Pgp inhibitors decrease the activity of Pgp.
 
Taking everolimus with one of these Pgp inhibitors causes everolimus to be removed from the body more slowly, potentially increasing everolimus blood levels, and increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely if you take everolimus with a Pgp inhibitor, and lower your dose if needed.
 
Pimecrolimus
Taking everolimus with pimecrolimus may increase your risk for potentially serious everolimus side effects, including infections and skin cancer. Although the risk for these serious side effects is rare, it is generally recommended that pimecrolimus not be used with medicines that weaken the immune system, including everolimus.
 
Sipuleucel-T
Sipuleucel-T works by stimulating the immune system, while everolimus is considered an immunosuppressant because it weakens the immune system. Therefore, everolimus could potentially decrease the effectiveness of sipuleucel-T. Talk with your healthcare provider before taking these medications together.
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Everolimus Drug Information

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