Drug Interactions With Everolimus

Cyclosporine
Using everolimus in combination with standard cyclosporine doses can increase the risk for kidney problems. Therefore, you will be given a lower dose of cyclosporine if you use everolimus to prevent kidney transplant rejection. Cyclosporine can also increase the amount of everolimus in your blood. Although these medicines are given together after a kidney transplant, the combination requires careful monitoring of everolimus and cyclosporine blood levels.
 
Denosumab
Combining everolimus with denosumab may increase your risk for potentially serious infections. Notify your healthcare provider right away if you develop any signs of an infection, such as:
 
  • Fever
  • Body aches
  • Chills.
 
Echinacea
Echinacea could decrease the effectiveness of everolimus. Do not take echinacea while taking everolimus without first talking with your healthcare provider.
 
Leflunomide
Combining everolimus with leflunomide may increase your risk for blood cell problems. Talk to your healthcare provider before taking these medications together. He or she may want to monitor your blood cell counts more closely.
 
Live Vaccinations
Because everolimus weakens the immune system, it is generally recommended that people not receive live vaccinations during everolimus treatment, and for at least three months after treatment ends. You should discuss this reaction with your healthcare provider before receiving a vaccination during everolimus treatment.
 
Natalizumab
Combining everolimus with natalizumab may increase your risk for potentially serious infections. In general, these medications should not be taken together.
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Everolimus Drug Information

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