Drug Interactions With Everolimus

More Detail on Drug Interactions With Everolimus

The following sections explain in detail the potentially negative reactions that can occur when everolimus is combined with any of the drugs listed above.
 
ACE Inhibitors
Everolimus may increase the risk of a potentially life-threatening reaction to ACE inhibitors known as angioedema. This condition causes swelling beneath the skin, usually around the lips and eyes. If swelling occurs in the mouth or tongue, it can block the airway.
 
Seek immediate medical attention if you develop signs of angioedema, including:
 
  • Swelling of the face or neck
  • Welts
  • Difficulty breathing.
 
CYP 3A4 Inducer Medications
The liver breaks down everolimus using enzymes known as CYP 3A4 enzymes. Some medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining everolimus with one of these CYP 3A4 inducers may decrease the level of everolimus in your body, potentially making it less effective. Your healthcare provider may need to monitor you more closely, and may need to increase your everolimus dose, if you take it with a CYP 3A4 inducer.
 
CYP 3A4 Inhibitor Medications
The liver breaks down everolimus using enzymes known as CYP 3A4 enzymes. Some medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining everolimus with one of these CYP 3A4 inhibitors may increase the level of everolimus in your body, increasing your risk for side effects.
 
Some CYP 3A4 inhibitors should not be taken with everolimus. Others may require an everolimus dosage adjustment, especially when you first start or stop the CYP 3A4 inhibitor. Check with your healthcare provider before taking a CYP 3A4 inhibitor during treatment with everolimus.
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Everolimus Drug Information

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